High Quality Guanidinoacetic Acidcas: 352-97-6
Mechanism of action Guanidinoacetic acid is a precursor of creatine. Phosphocreatine, which contains high phosphate group transfer potential energy, is widely present in muscle and nerve tissues and is the main energy supply substance in animal muscle tissues. The addition of guanidinoacetic acid makes the body produce a large number of phosphate group transfer substances (creatine phosphate), so as to provide power for the efficient work of muscles, brain, gonads and other tissues, and promote the continuous distribution of energy to muscle tissues.
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Application
It is used as feed additive and organic synthesis intermediate.
1. Improvement of animal body shape: creatine phosphate is only abundant in muscle and nerve tissue, with little content in adipose tissue, so it can promote the transfer of energy to muscle tissue. The improvement of lean pig body shape is particularly significant, with wide back and plump buttocks.
2, promote the growth of livestock and poultry fish and shrimp: guanidinoacetic acid is a precursor of creatine, stable performance, high absorption rate, can promote the distribution of energy to muscle tissue synthesis. The weight gain of livestock and poultry increased by more than 7%, and the growth rate of fish and shrimp increased by 8%. Guanidinoacetic acid was used in the 50-100kg stage to reduce the meat ratio by 0.2, and the growth and finishing were put out of the barn 7-10 days earlier, saving more than 15kg of feed per pig.
The administration of guanidinoacetic acid had no significant effect on the enzyme expression profile of human liver and muscle, and the side effects of guanidinoacetic acid administration were acceptable, such as weight gain, nausea, abdominal distension, muscle cramps, and abdominal pain. However, it is worth noting that in addition to increasing serum creatinine and creatine content in muscle, taking guanidinoacetic acid can also increase serum homocysteine content. This is due to the fact that guanidinoacetic acid is methylated to form creatine while also being able to form S-adenosine homocysteine, which is then hydrolyzed to cysteine and adenosine in vivo. Since serum homocysteine is a clinically important indicator of atherosclerosis and cardiovascular diseases, the intake of guanidinoacetic acid increases plasma homocysteine content, which can be considered as a side effect of guanidinoacetic acid.
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