Sodium Bicarbonate Solid

Sodium bicarbonate solid

Specification

Sodium bicarbonate (NaHCO3), also known as baking soda or sodium bicarbonate, is a white crystalline solid or powder.White crystalline powder or granule, odorless, slightly alkaline,Soluble in water (10 g/100 mL water at 20°C), slightly soluble in methanol and acetic acid, insoluble in ethanol.

Application

Tablets may also be prepared with sodium bicarbonate alone since the acid of gastric fluid is sufficient to cause effervescence and disintegration. It is also used in tablet formulations to buffer drug molecules that are weak acids, thereby increasing the rate of tablet dissolution and reducing gastric irritation.
The effects of tablet binders, such as polyethylene glycols, microcrystalline cellulose, silicified microcrystalline cellulose, pregelatinized starch, and povidone, on the physical and mechanical properties of it tablets have also been investigated.( 8,9) Additionally,it is used in solutions as a buffering agent for erythromycin, lidocaine, local anesthetic solutions, and total parenteral nutrition (TPN) solutions. In some parenteral formulations, e.g. niacin, it is used to produce a sodium salt of the active ingredient that has enhanced solubility. it has also been used as a freeze-drying stabilizer and in toothpastes.

ut has been used as a gas-forming agent in alginate raft systems and in floating, controlledrelease oral dosage forms for a range of drugs. Tablet formulations containing it have been shown to increase the absorption of paracetamol, and improve the stability of levothyroxine. ut has also been included in formulations of vaginal bioadhesive tablets and in carbon dioxide releasing suppositories.

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